abstract：:The endothelium, as the interface between blood and all tissues, plays a critical role in inflammation. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid, highly abundant in plasma, that potently regulates endothelial responses through interaction with its receptors (S1PRs). Here, we studied the role of S1PR2 ...

journal_title：Blood

authors： Zhang G,Yang L,Kim GS,Ryan K,Lu S,O'Donnell RK,Spokes K,Shapiro N,Aird WC,Kluk MJ,Yano K,Sanchez T

更新日期：2013-07-18 00:00:00

abstract：:Outcome in multiple myeloma is highly variable and a better understanding of the factors that influence disease biology is essential to understand and predict behavior in individual patients. In the present study, we analyzed combined genomewide DNA methylation and gene expression data of patients treated in the Medic...

journal_title：Blood

authors： Kaiser MF,Johnson DC,Wu P,Walker BA,Brioli A,Mirabella F,Wardell CP,Melchor L,Davies FE,Morgan GJ

更新日期：2013-07-11 00:00:00

abstract：:Mutations of the NPM1 gene (NPM1mut) are among the most common genetic alterations in acute myeloid leukemia and are suitable for minimal residual disease detection. We retrospectively investigated the prognostic impact of NPM1mut-based minimal residual disease detection from bone marrow for development of relapse by ...

journal_title：Blood

authors： Shayegi N,Kramer M,Bornhäuser M,Schaich M,Schetelig J,Platzbecker U,Röllig C,Heiderich C,Landt O,Ehninger G,Thiede C,Study Alliance Leukemia (SAL).

更新日期：2013-07-04 00:00:00

abstract：:Familial hemophagocytic lymphohistiocytosis (FHL) is caused by genetic defects in cytotoxic granule components or their fusion machinery, leading to impaired natural killer cell and/or T lymphocyte degranulation and/or cytotoxicity. This may accumulate into a life-threatening condition known as macrophage activation s...

journal_title：Blood

authors： Zhao XW,Gazendam RP,Drewniak A,van Houdt M,Tool AT,van Hamme JL,Kustiawan I,Meijer AB,Janssen H,Russell DG,van de Corput L,Tesselaar K,Boelens JJ,Kuhnle I,Van Der Werff Ten Bosch J,Kuijpers TW,van den Berg TK

更新日期：2013-07-04 00:00:00

abstract：:Mutations in the nucleophosmin 1 (NPM1) gene are considered a founder event in the pathogenesis of acute myeloid leukemia (AML). To address the role of clonal evolution in relapsed NPM1-mutated (NPM1mut) AML, we applied high-resolution, genome-wide, single-nucleotide polymorphism array profiling to detect copy number ...

journal_title：Blood

authors： Krönke J,Bullinger L,Teleanu V,Tschürtz F,Gaidzik VI,Kühn MW,Rücker FG,Holzmann K,Paschka P,Kapp-Schwörer S,Späth D,Kindler T,Schittenhelm M,Krauter J,Ganser A,Göhring G,Schlegelberger B,Schlenk RF,Döhner H,Döhner K

更新日期：2013-07-04 00:00:00

abstract：:Humans and mice with impaired perforin-dependent cytotoxic function may develop excessive T-cell activation and the fatal disorder hemophagocytic lymphohistiocytosis (HLH) after infection. Though cytotoxic lymphocytes can kill antigen-presenting cells, the physiological mechanism of perforin-mediated immune regulation...

journal_title：Blood

authors： Terrell CE,Jordan MB

更新日期：2013-06-27 00:00:00

abstract：:Severe congenital neutropenia as well as primary myelofibrosis are rare in infancy. Elucidation of the underlying mechanism is important because it extends our understanding of the more common adult forms of these disorders. Using homozygosity mapping followed by exome sequencing, we identified a Thr224Asn mutation in...

journal_title：Blood

authors： Stepensky P,Saada A,Cowan M,Tabib A,Fischer U,Berkun Y,Saleh H,Simanovsky N,Kogot-Levin A,Weintraub M,Ganaiem H,Shaag A,Zenvirt S,Borkhardt A,Elpeleg O,Bryant NJ,Mevorach D

更新日期：2013-06-20 00:00:00

abstract：:Hematopoiesis is a tightly regulated process resulting in the production of blood cells. Self-renewal and differentiation of hematopoietic stem cells (HSCs) are key processes in hematopoietic development. Disruption of these steps can lead to altered cell distribution and disease. To investigate the role of the nuclea...

journal_title：Blood

authors： Stein SJ,Baldwin AS

更新日期：2013-06-20 00:00:00

abstract：:The immunoreceptors NKG2D and NKp46 are known for their capacity to activate natural killer (NK) cell cytotoxicity and secretory responses in the contexts of tumors and infections, yet their roles in NK cell education remain unclear. Here, we provide the first characterization of mice deficient for both NKG2D and NKp4...

journal_title：Blood

authors： Sheppard S,Triulzi C,Ardolino M,Serna D,Zhang L,Raulet DH,Guerra N

更新日期：2013-06-20 00:00:00

abstract：:The MLLT10 gene, located at 10p13, is a known partner of MLL and PICALM in specific leukemic fusions generated from recurrent 11q23 and 11q14 chromosome translocations. Deep sequencing recently identified NAP1L1/12q21 as another MLLT10 partner in T-cell acute lymphoblastic leukemia (T-ALL). In pediatric T-ALL, we have...

journal_title：Blood

authors： Brandimarte L,Pierini V,Di Giacomo D,Borga C,Nozza F,Gorello P,Giordan M,Cazzaniga G,Te Kronnie G,La Starza R,Mecucci C

更新日期：2013-06-20 00:00:00

abstract：:Genome and transcriptome sequencing have revealed a rich assortment of noncoding RNAs in eukaryote cells, including long noncoding RNAs (lncRNAs), which regulate gene expression independent of protein coding potential. LncRNAs modulate protein coding gene expression in many cell types by regulating multiple processes,...

journal_title：Blood

authors： Paralkar VR,Weiss MJ

更新日期：2013-06-13 00:00:00

abstract：:Recruitment of polymorphonuclear neutrophils (PMNs) to sites of acute inflammation critically depends on β2 integrins (CD11/CD18). Recently, the mammalian actin-binding protein 1 (mAbp1) was identified as an important adaptor protein regulating PMN trafficking downstream of β2 integrins. Here, we show that mAbp1 const...

journal_title：Blood

authors： Jakob SM,Pick R,Brechtefeld D,Nussbaum C,Kiefer F,Sperandio M,Walzog B

更新日期：2013-05-16 00:00:00

abstract：:Ecotropic viral integration site 1 (Evi1) is one of the master regulators in the development of acute myeloid leukemia (AML) and myelodysplastic syndrome. High expression of Evi1 is found in 10% of patients with AML and indicates a poor outcome. Several recent studies have indicated that Evi1 requires collaborative fa...

journal_title：Blood

authors： Watanabe-Okochi N,Yoshimi A,Sato T,Ikeda T,Kumano K,Taoka K,Satoh Y,Shinohara A,Tsuruta T,Masuda A,Yokota H,Yatomi Y,Takahashi K,Kitaura J,Kitamura T,Kurokawa M

更新日期：2013-05-16 00:00:00

abstract：:Mixed-lineage leukemia (MLL)-AF4 fusion arises prenatally in high-risk infant acute pro-B-lymphoblastic leukemia (pro-B-ALL). In human embryonic stem cells (hESCs), MLL-AF4 skewed hematoendothelial specification but was insufficient for transformation, suggesting that additional oncogenic insults seem required for MLL...

journal_title：Blood

authors： Bueno C,Ayllón V,Montes R,Navarro-Montero O,Ramos-Mejia V,Real PJ,Romero-Moya D,Araúzo-Bravo MJ,Menendez P

更新日期：2013-05-09 00:00:00

abstract：:Hoyeraal Hreidarsson syndrome (HHS) is a form of dyskeratosis congenita (DC) characterized by bone marrow failure, intrauterine growth retardation, developmental delay, microcephaly, cerebellar hypoplasia, immunodeficiency, and extremely short telomeres. As with DC, mutations in genes encoding factors required for tel...

journal_title：Blood

authors： Gramatges MM,Qi X,Sasa GS,Chen JJ,Bertuch AA

更新日期：2013-05-02 00:00:00

abstract：:In patients with chronic myeloid leukemia, BCR-ABL mutations contribute to resistance to tyrosine kinase inhibitor therapy. We examined the occurrence of treatment-emergent mutations and their impact on response in patients from the ENESTnd phase 3 trial. At the 3-year data cutoff, mutations were detected in approxima...

journal_title：Blood

authors： Hochhaus A,Saglio G,Larson RA,Kim DW,Etienne G,Rosti G,De Souza C,Kurokawa M,Kalaycio ME,Hoenekopp A,Fan X,Shou Y,Kantarjian HM,Hughes TP

更新日期：2013-05-02 00:00:00

abstract：:Translocations in myeloma are thought to occur solely in mature B cells in the germinal center through class switch recombination (CSR). We used a targeted captured technique followed by massively parallel sequencing to determine the exact breakpoints in both the immunoglobulin heavy chain (IGH) locus and the partner ...

journal_title：Blood

authors： Walker BA,Wardell CP,Johnson DC,Kaiser MF,Begum DB,Dahir NB,Ross FM,Davies FE,Gonzalez D,Morgan GJ

更新日期：2013-04-25 00:00:00

abstract：:Vascular tube morphogenesis requires the establishment of endothelial cell (EC) apical-basal polarity in three-dimensional (3D) extracellular matrices. To date, there is little understanding of how EC polarity is controlled during these highly dynamic and rapid morphogenic events. We show that the microtubule tip comp...

journal_title：Blood

authors： Kim DJ,Martinez-Lemus LA,Davis GE

更新日期：2013-04-25 00:00:00

abstract：:In this issue of Blood, Leonhardt et al report that neovascularization during graft-versus-host disease (GVHD) is regulated by av integrins and the micro RNA miR-100. ...

journal_title：Blood

authors： Komanduri KV

更新日期：2013-04-25 00:00:00

abstract：:Indolent systemic mastocytosis (SM) patients have a varied clinical presentation, ranging from predominantly cutaneous symptoms to recurrent systemic symptoms (eg, flushing, palpitations, dyspepsia, diarrhea, bone pain) that can be severe and potentially life threatening (anaphylaxis). Mastocytosis patients without sk...

journal_title：Blood

authors： Pardanani A

更新日期：2013-04-18 00:00:00

abstract：:The functional activities of the tumor suppressor promyelocytic leukemia protein (PML) are mostly associated with its nuclear location. In the present study, we discovered an unexpected role of PML in NLRP3 inflammasome activation. In PML-deficient macrophages, the production of IL-1β was strongly impaired. The expres...

journal_title：Blood

authors： Lo YH,Huang YW,Wu YH,Tsai CS,Lin YC,Mo ST,Kuo WC,Chuang YT,Jiang ST,Shih HM,Lai MZ

更新日期：2013-04-18 00:00:00

abstract：:Terminal erythroid differentiation starts from morphologically recognizable proerythroblasts that proliferate and differentiate to generate red cells. Although this process has been extensively studied in mice, its characterization in humans is limited. By examining the dynamic changes of expression of membrane protei...

journal_title：Blood

authors： Hu J,Liu J,Xue F,Halverson G,Reid M,Guo A,Chen L,Raza A,Galili N,Jaffray J,Lane J,Chasis JA,Taylor N,Mohandas N,An X

更新日期：2013-04-18 00:00:00

abstract：:Survival in infants younger than 1 year who have acute lymphoblastic leukemia (ALL) is inferior whether MLL is rearranged (R) or germline (G). MLL translocations confer chemotherapy resistance, and infants experience excess complications. We characterized in vitro sensitivity to the pan-antiapoptotic BCL-2 family inhi...

journal_title：Blood

authors： Urtishak KA,Edwards AY,Wang LS,Hudome A,Robinson BW,Barrett JS,Cao K,Cory L,Moore JS,Bantly AD,Yu QC,Chen IM,Atlas SR,Willman CL,Kundu M,Carroll AJ,Heerema NA,Devidas M,Hilden JM,Dreyer ZE,Hunger SP,Reaman GH,

更新日期：2013-04-04 00:00:00

abstract：:Natural killer (NK) cells participate in host defense by surveying for and ultimately killing virally infected or malignant target cells. NK cell cytotoxicity is a tightly regulated process that proceeds stepwise from adhesion and activation to the secretion of preformed lytic granule contents onto a diseased or stres...

journal_title：Blood

authors： James AM,Hsu HT,Dongre P,Uzel G,Mace EM,Banerjee PP,Orange JS

更新日期：2013-04-04 00:00:00

abstract：:Regulated migration of hematopoietic stem cells is fundamental for hematopoiesis. The molecular mechanisms underlying stem cell trafficking are poorly defined. Based on a short hairpin RNA library and stromal cell-derived factor-1 (SDF-1) migration screening assay, we identified the histone 3 lysine 27 demethylase UTX...

journal_title：Blood

authors： Thieme S,Gyárfás T,Richter C,Özhan G,Fu J,Alexopoulou D,Muders MH,Michalk I,Jakob C,Dahl A,Klink B,Bandola J,Bachmann M,Schröck E,Buchholz F,Stewart AF,Weidinger G,Anastassiadis K,Brenner S

更新日期：2013-03-28 00:00:00

abstract：:The p21-activated kinases (Paks) are serine/threonine kinases that are major effectors of the Rho guanosine 5'\x{2011}triphosphatase, Rac, and Cdc42. Rac and Cdc42 are known regulators of hematopoietic stem and progenitor cell (HSPC) function, however, a direct role for Paks in HSPCs has yet to be elucidated. Lin(-)Sc...

journal_title：Blood

authors： Dorrance AM,De Vita S,Radu M,Reddy PN,McGuinness MK,Harris CE,Mathieu R,Lane SW,Kosoff R,Milsom MD,Chernoff J,Williams DA

更新日期：2013-03-28 00:00:00

abstract：:Enteropathy-associated T-cell lymphoma (EATL) is a rare subtype of peripheral T-cell lymphomas with a poor prognosis. Autologous stem cell transplantation (ASCT) was retrospectively evaluated as a consolidation or salvage strategy for EATL. The analysis included 44 patients who received ASCT for EATL between 2000 and ...

journal_title：Blood

authors： Jantunen E,Boumendil A,Finel H,Luan JJ,Johnson P,Rambaldi A,Haynes A,Duchosal MA,Bethge W,Biron P,Carlson K,Craddock C,Rudin C,Finke J,Salles G,Kroschinsky F,Sureda A,Dreger P,Lymphoma Working Party of the EBMT.

更新日期：2013-03-28 00:00:00

abstract：:As acute myeloid leukemia (AML) xenograft models improve, the potential for using them to evaluate novel therapeutic strategies becomes more appealing. Currently, there is little information on using standard chemotherapy regimens in AML xenografts. Here we have characterized the immunodeficient mouse response to comb...

journal_title：Blood

authors： Wunderlich M,Mizukawa B,Chou FS,Sexton C,Shrestha M,Saunthararajah Y,Mulloy JC

更新日期：2013-03-21 00:00:00

abstract：:Mantle cell lymphoma (MCL) is one of the most aggressive lymphoid neoplasms whose pathogenesis is not fully understood. The neural transcription factor SOX11 is overexpressed in most MCL but is not detected in other mature B-cell lymphomas or normal lymphoid cells. The specific expression of SOX11 in MCL suggests that...

journal_title：Blood

authors： Vegliante MC,Palomero J,Pérez-Galán P,Roué G,Castellano G,Navarro A,Clot G,Moros A,Suárez-Cisneros H,Beà S,Hernández L,Enjuanes A,Jares P,Villamor N,Colomer D,Martín-Subero JI,Campo E,Amador V

更新日期：2013-03-21 00:00:00

abstract：:HS1 (hematopoietic cell-specific Lyn substrate-1) is a cytoskeletal interactor in the B-cell receptor (BCR) signaling pathway whose phosphorylation correlates with prognosis in Chronic Lymphocytic Leukemia (CLL). The differentially phosphorylated sites and the kinases that regulate HS1 activity in CLL remain poorly un...

journal_title：Blood

authors： ten Hacken E,Scielzo C,Bertilaccio MT,Scarfò L,Apollonio B,Barbaglio F,Stamatopoulos K,Ponzoni M,Ghia P,Caligaris-Cappio F

更新日期：2013-03-21 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) regulates hematopoietic stem/progenitor cell (HSPC) activity. However, the receptor(s) responsible for PGE(2) signaling remains unclear. Here, we identified EP4 as a receptor activated by PGE(2) to regulate HSPCs. Knockdown of Ep4 in HSPCs reduced long-term reconstitution capacity, whereas ...

journal_title：Blood

authors： Ikushima YM,Arai F,Hosokawa K,Toyama H,Takubo K,Furuyashiki T,Narumiya S,Suda T

更新日期：2013-03-14 00:00:00

abstract：:Donor hematopoietic stem cells (HSCs) can correct T-cell deficiencies in patients with severe combined immunodeficiency by replacing resident thymus cells. However, as those progenitors that naturally migrate to the thymus are not capable of supporting long-term thymopoiesis, a successful transplant is thought to requ...

journal_title：Blood

authors： de Barros SC,Vicente R,Chebli K,Jacquet C,Zimmermann VS,Taylor N

更新日期：2013-03-14 00:00:00

abstract：:In this issue of Blood, Smith and colleagues report on the functional role of the interaction between these 2 proteins by studying the involved binding sites responsible for clot stabilization.(1) ...

journal_title：Blood

authors： Kohler HP

更新日期：2013-03-14 00:00:00

abstract：:Low molecular weight heparin (LMWH) is being tested as an experimental drug for improving pregnancy outcome in women with inherited thrombophilia and placenta-mediated pregnancy complications, such as recurrent pregnancy loss. The role of thrombotic processes in these disorders remains unproven, and the issue of antit...

journal_title：Blood

authors： An J,Waitara MS,Bordas M,Arumugam V,Hoffmann RG,Petrich BG,Sinha U,North PE,Sood R

更新日期：2013-03-14 00:00:00

abstract：:Histone deacetylases (HDACs) are epigenetic erasers of lysine-acetyl marks. Inhibition of HDACs using small molecule inhibitors (HDACi) is a potential strategy in the treatment of various diseases and is approved for treating hematological malignancies. Harnessing the therapeutic potential of HDACi requires knowledge ...

journal_title：Blood

authors： Heideman MR,Wilting RH,Yanover E,Velds A,de Jong J,Kerkhoven RM,Jacobs H,Wessels LF,Dannenberg JH

更新日期：2013-03-14 00:00:00

abstract：:Monocytes regulate host defenses, inflammation, and tissue homeostasis. The transcription factor interferon regulatory factor-8 (IRF8) stimulates monocyte/macrophage differentiation, yet genome-wide understanding of the differentiation program initiated by IRF8 is lacking. By combining chromatin immunoprecipitation se...

journal_title：Blood

authors： Kurotaki D,Osato N,Nishiyama A,Yamamoto M,Ban T,Sato H,Nakabayashi J,Umehara M,Miyake N,Matsumoto N,Nakazawa M,Ozato K,Tamura T

更新日期：2013-03-07 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) play an important role in the regulation of the immune response. MDSC expansion occurs in many circumstances, including cancer, inflammation, stresses, and transplant tolerance. Liver transplants in mice are spontaneously accepted, but hepatocyte transplants are acutely rejecte...

journal_title：Blood

authors： Hsieh CC,Chou HS,Yang HR,Lin F,Bhatt S,Qin J,Wang L,Fung JJ,Qian S,Lu L

更新日期：2013-03-07 00:00:00

abstract：:Scott syndrome, a bleeding disorder caused by defective phospholipid scrambling, has been associated with mutations in the TMEM16F gene. The role of TMEM16F in apoptosis- or agonist-induced phosphatidylserine (PS) exposure was studied in platelets from a Scott syndrome patient and control subjects. Whereas stimulation...

journal_title：Blood

authors： van Kruchten R,Mattheij NJ,Saunders C,Feijge MA,Swieringa F,Wolfs JL,Collins PW,Heemskerk JW,Bevers EM

更新日期：2013-03-07 00:00:00

abstract：:Malignant transformation by oncogenes requires additional genetic/epigenetic changes to overcome enhanced susceptibility to apoptosis. In the present study, we report that Bif-1 (Sh3glb1), a gene encoding a membrane curvature–driving endophilin protein, is a haploinsufficient tumor suppressor that plays a key role in ...

journal_title：Blood

authors： Takahashi Y,Hori T,Cooper TK,Liao J,Desai N,Serfass JM,Young MM,Park S,Izu Y,Wang HG

更新日期：2013-02-28 00:00:00

abstract：:Receptors for the Fc portion of IgG (FcγRs) are mandatory for the induction of various IgG-dependent models of autoimmunity, inflammation, anaphylaxis, and cancer immunotherapy. A few FcγRs have the ability to bind monomeric IgG: high-affinity mouse mFcγRI, mFcγRIV, and human hFcγRI. All others bind IgG only when aggr...

journal_title：Blood

authors： Mancardi DA,Albanesi M,Jönsson F,Iannascoli B,Van Rooijen N,Kang X,England P,Daëron M,Bruhns P

更新日期：2013-02-28 00:00:00